Intramuscular arteether for treating severe malaria
نویسندگان
چکیده
منابع مشابه
Artesunate versus quinine for treating severe malaria.
BACKGROUND Severe malaria results in over a million deaths every year, most of them in children aged under five years and living in sub-Saharan Africa. This review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes. OBJECTIVES To compare artesunate with quinine for treating severe malaria. SEARCH ...
متن کاملArtemisinin derivatives for treating severe malaria.
BACKGROUND Artemisinin derivatives may have advantages over quinoline drugs for treating severe malaria since they are fast acting and effective against quinine resistant malaria parasites. OBJECTIVES The objective of this review was to assess the effects of artemisinin drugs for severe and complicated falciparum malaria in adults and children. SEARCH STRATEGY We searched the Cochrane Infec...
متن کاملTreating severe malaria: artesunate or quinine?
Severe (complicated) malaria caused by Plasmodium falciparum kills over a million people every year. The annual death toll can be as high as one in 100 children under the age of five(1). Intravenous infusion of quinine is recommended as an initial therapy for these children. Recent years have witnessed increasing use of artemisinin derivatives (mainly artesunate) in the treatment of severe mala...
متن کاملHigh first dose quinine regimen for treating severe malaria.
BACKGROUND Quinine is used for treating severe malaria. There are arguments for giving an initial high dose. We examined the evidence for and against this policy. OBJECTIVES To assess clinical outcomes and adverse events of a high first (loading) dose regimen of quinine with a uniform (no loading) dose regimen in people with severe malaria. SEARCH STRATEGY We searched the Cochrane Infectiou...
متن کاملPopulation pharmacokinetics of intramuscular quinine in children with severe malaria.
We present the first population pharmacokinetic analysis of quinine in patients with Plasmodium falciparum malaria. Ghanaian children (n = 120; aged 12 months to 10 years) with severe malaria received an intramuscular loading dose of quinine dihydrochloride (20 mg/kg of body weight). A two-compartment model with first-order absorption and elimination gave post hoc estimates for pharmacokinetic ...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2004
ISSN: 1465-1858
DOI: 10.1002/14651858.cd004391.pub2